Definition and Meaning of PSC
Primary sclerosing cholangitis (PSC) is a condition where the bile ducts are diseased and become thick, hard and narrow. This prevents the flow of bile through the ducts. Although there are many diseases that can damage the bile duct (secondary cholangitis), in primary sclerosing cholangitis there is no underlying disease that can be identified which affects the bile ducts. It appears to occur independently. Over time the narrowing can reach a point where the bile duct is almost entirely occluded with a complete stoppage of bile flow. It may lead to severe and even permanent damage of the liver which can then progress to liver failure.