The genomics scientists of Philadelphia are duplicated gene-linked research of another group with regard to obesity and came out with interesting conclusions. This extended research bettered an indicator to a specific variant of DNA. This means identification of a gene associated with obesity across the world is possible. Once the gene is identified, it can be sliced and tailor used according to various needs.
The research findings suggest that the DNA variant which was spotted in the African-American children could be indicating of the primitive DNA change that happened in the black continent, the place from where supposedly man originated.
The Children’s Hospital of Philadelphia, Center for Applied Genomics scientists’ team, Struan Grant et al studied the FTO gene that was identified by erstwhile British Scientists’ team during last year. The FTO gene was associated with the obesity in children and adults. There is no discount to the point that environment conditions contribute to obesity, the gene cannot be ruled out and obesity is controlled by familial genes.
The British team’s findings say that FTO gene is associated with obesity in Caucasians. The Caucasian and African-American children’s samples, irrespective of obesity, were studied by the Philadelphia team, via genetic screening methodology. They came out with similar DNA variant with respect to the Caucasian children. There was another DNA variant, seen in the African-American and the Caucasian children’s DNA samples, happened to be marker that is associated to obesity with African-American children. Surprisingly the two DNA variants are due to a mutation to the chemical base on same strand of the DNA. This is termed as SNP or single nucleotide polymorphism.
The findings of Struan Grant et al will assist researchers in genomics with respect to first SNP in those people with African descent, as they would not have any correlation to obesity; however, the second SNP could show some links of evolution. Researchers have strong proof that Homo sapiens originated from African continent and the SNP would be a result of mutation or change happened long back that would have triggered a human inclination to obesity.
Mutations of FTO gene will have the risk of resulting in obesity in adults as well as children. However, this points to another interesting thing that FTO which is obesity linked starts in childhood itself. Struan Grant et al team is keen to continue their genomics research to track more DNA variants for the FTO gene that could be linked to obesity. If their research comes up with some results it would surely pave way for treating obesity via FTO gene pathway. Having said and done there is still a long way to go for this to materialize.
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