New study reveals promising results

Polycystic kidney disease

FRIDAY, April 11 (HealthDay News) — The University of California, San Francisco, School of Medicine made a new research that indicated to slow down the growth of Polycystic kidney disease (PKD) by inhibitors compounds known as CFTR.

Inherited kidney disease

PKD is considered a common inherited kidney disease and patients with that disease have small bubble sort of cysts on the Kidneys that gradually increase not only in mass but also in numbers. The Kidneys get large in size and it, ultimately, turns into kidney failure. There is still no treatment for PKD.

Chloride secretion

It’s believed the accumulation of fluid in the cysts is related to chloride secretion, which is affect by the CFTR (cystic fibrosis transmembrane conductance regulator) gene, according to some information in a news release about the research.

PolycysticKidney

Fluid in the cysts

In this news it has been described that the research proves chloride secretion as the basic reason behind addition of fluid in the tiny cysts. This chloride secretion has an effect on CFTR (cystic fibrosis transmembrane conductance regulator) gene.

Treating PKD

According to researcher Dr.Alan S. Verkman “The CFTR substance could be the foundation of a lasting treatment to slow renal cyst increase and decrease in renal function, and expand dialysis-free patient existence,”

He found in lab tests that some CFTR substances decreased the growth and number of cysts even more than 80 %. Later, these slowing substances were tested by him in genetically engineered mice with a developed state same as PKD.

Lower cyst growth in mince

The result showed that the Mice who were treated with these CFTR substances till seven days had considerably lower cyst growth and kidney swelling. They didn’t find any record that proved CFTR substances harmful for kidney function.

Verkman is of the view that the results of the research prove that CFTR is basic reason behind cysts growth in the Kidney and CFTR slowing down substances can prove helpful in treating PKD. He further adds that much more is still required in this connection.
It is expected that the research will be published in Journal of the American Society of Nephrology in July.

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