“Severe Human Respiratory Syncytial Virus (hRSV)” appears to cause “Bronchiolitis” both via a reduced local interferon (IFN) – ? response and substance P-mediated inflammation.
Malcolm Semple and his team of other UK researchers at the “University of Liverpool” have discovered this after the conclusion of a research study. Findings of this study have been published in the journal “PLoS ONE” recently.
The researchers believe that the research study results clearly indicate about the infants’ susceptibility to severe hRSV bronchiolitis and this may depend on innate immune responses to the virus.
Malcolm Semple went on to explore the factors that may mediate proposed mechanisms for bronchiolitis. His research team then studied 197 infants admitted to hospital with hRSV. All these infants were subsequently divided into groups like 27 with no oxygen requirement, 114 who were dependent on oxygen, and 56 who needed mechanical ventilation.
