Esophagitis is the inflammation of the esophageal lining and/or wall. The are various types of esophagitis classified according to the causative factor(s) which may also be an extension of the different types of gastritis.
This is the most common type of esophagitis associated with gastroesophageal reflux disease. The backflow of the stomach contents damages the lining of the esophagus often leading to ulcer formation.
Although the esophageal lining contains mucus secreting glands which protects the esophagus against gastric acid, repeated episodes and persistent reflux will lead to mucosal injury. The lower esophageal sphincter(LES) prevents the backflow of gastric contents but when malfunctioning, the gastric acid can easily enter the esophagus and sometimes rise as high up as the throat.
Factors that contribute to decreased tone of the LES includes :
- Cigarette smoking
- Hiatal hernia
- Various causes of delayed gastric emptying
Also known as pill-induced or medication esophagitis, the inflammation is caused by drugs which are temporarily lodged in the esophagus. This may be seen in cases of esophageal strictures, where the narrowing slows or temporarily halts the transit of substances down the esophagus. By partially dissolving within the esophagus over a period of time, these drugs may inflame and ulcerate the esophagus.
The strictures may be a result of fibrosis related to other types of esophagitis, esophageal cancer or benign tumors.
The most likely drugs to cause this level of esophageal irritation includes :
- NSAID’s including aspirin
- Alendronate (for osteoporosis)
- Antibiotics like doxycycline or tetracycline
This type of esophagitis includes reflux and drug-induced esophagitis. It is sometimes broadly classified under chemical esophagitis. In addition, corrosive substances which are ingested either intentionally or accidentally may cause inflammation of the esophagus and ulceration of the lining. Substances that may cause chemical esophagitis, apart from gastric acid and drugs, includes :
- Strong alkalines (lyes)
- Strong acids
- Mechanical lubricants and industrial additives
This occurs as a result of the infiltration of high quantities of immune cells which are responsible for inflammation into the wall of the esophagus. It is believed to stem from an immune-mediate hypersensitivity (allergy) as it is often seen in patients with the triad of allergic conditions – atopic dermatitis, allergic rhinitis and asthma. This type of esophagitis may be aggravated by dietary factors, particularly allergenic foods like cow’s milk.
This type of esophagus arises as a result of an infection of the esophagus, spread from neighboring sites (mouth, throat or stomach) or systemic infections. This is more often seen with viral and fungal infections.
Some of the more common causes include :
- Herpes simplex
- Cytomegalovirus (CMV)
- Candida species (esophageal candidiasis)
- Rare – mucomycosis, aspergillosis
- Non-pathogenic oral bacteria – secondary infection of an esophageal ulcer
- Pathogenic bacteria like Mycobacteriium tuberculosis and Mycobacterium avium-intracellulare
- Trypanosoma cruzi – Chagas disease
HIV testing is always worth considering in a case of infectious esophagitis as many of these infections are opportunistic. Chronic granulomatous disease may be another contributing factor to the development of recurrent infectious esophagitis.
Other Causes of Esophagitis
- Radiation esophagitis
- This type of esophagitis arises as a side effect of radiation therapy and is often associated with mucositis (inflammation of the mouth, gums and throat).
- Esophagitis related to inflammatory bowel disease
- This is rare but may be linked to Crohn’s disease.
- Esophagitis due to desquamative skin diseases
- Another rare cause of esophagitis when conditions like bullous pemphigoid, epidermolysis bullosa,lichen planus and leukoplakia involves the esophagus.
- Esophagitis due to inhaled toxins
- This may be due to lifestyle factors as seen with cigarette smoking or gases associated with environmental pollution.