Malabsorption is the term for impaired absorption of nutrients from food in the gut. Most absorption occurs within the intestines but the other parts of the gut (gastrointestinal tract) play important roles in digestion which prepares the food for absorption.

Malabsorption often results in deficiencies and the signs and symptoms that may arise are due to this lack of specific nutrients within the body. Other clinical features may not be related to deficiency but are a part of the causative disease or disorder that results in malabsorption.

How does a malabsorption disorder occur?

Pathophysiology of Malabsorption

There are a number of causes of malabsorption and this may be due to disorders affecting the gut itself or other diseases that contribute to impaired nutrient absorption.

Malabsorption may occur due to one of the following processes :

Impaired Digestion (Maldigestion)

In this process, the food is not broken down sufficiently to allow for absorption within the small intestines Digestion is a combination of mechanical and chemical processes. Mechanical digestion involves the breaking of the food physically (example : action of teeth, churning in the stomach). Chemical digestion involves the digestive enzymes which are secreted in the mouth, stomach and small intestine.

Any impairment in the structures or compounds for mechanical and/or chemical digestion (digestive enzymes) affect the overall digestive process. The intestinal contents are therefore not sufficiently broken down to be absorbed into the bloodstream.

Examples :

  • Deficiency of pancreatic enzymes or bile may impair hydrolysis and solubilization (chemical digestion).
  • Gastric bypass surgery can impair the stomach muscles and affect the churning of food (mechanical digestion).

Impaired Absorption (Malabsorption)

Most nutrients are absorbed in the small intestine. The anatomical characteristics (surface area and permeability) of the small intestine have developed to carry out of the process of absorption. If the surface area or permeability of the epithelium lining the inside of the intestine is affected then nutrients cannot enter the cells and be transported by the  bloodstream.

Examples :

  • Surgical removal (resection) of the small intestine decreases the surface area for nutrient absorption.
  • Inflammatory bowel disease causes swelling of the intestinal mucosa which reduces the surface area created by the villi and impairs nutrient transport into the bloodstream.

Lymphatic Obstruction (Blockage)

Any blockage affecting the lymphatic drainage will hamper the uptake of lipids (fats) by the lacteals and the subsequent transport of  these nutrients. In addition, the lymphatic obstruction results in an increased pressure within the lacteals. This will cause it to “leak” proteins into the intestinal lumen which is known as protein-losing enteropathy secondary to lymphatic obstruction.

Signs and Symptoms of Malabsorption

  • Chronic diarrhea (>3 stools per day, >200g/200ml of stool per day persisting for more than 30 days) although normal bowel movements and patterns may be present in some cases.
    • The diarrhea is often watery and of a large volume typical of diarrhea due to small bowel disturbances.
    • It may be pale with an offensive odor.
    • ‘Floaters’ – stools float in the toilet water (steatorrhea).
    • Undigested food may be seen in the stools.
  • Borborygmi – loud gastrointestinal noises (rumbling, growling).
  • Intestinal cramps.
  • Abdominal distension.
  • Unintentional weight loss – failure to thrive (FTT) in children.
  • Fatigue.

The clinical features of malabsorption (signs and symptoms of deficiencies) may cause additional signs and symptoms that are not mentioned above.

Related Articles

  1. Vitamin Deficiencies in Malabsorption Syndromes
  2. Pancreatic Enzyme Deficiency
  3. Fructose Malabsorption

Article reviewed by Dr. Greg. Last updated on August 19, 2010